Pradeep Natarajan (Broad Institute) and colleagues lead a study site aimed at addressing key gaps in the current ability to deliver polygenic scores accurately to diverse populations. First, they propose to harmonize and aggregate individual-level data from >50,000 individuals of South Asian ancestry – prioritized on the basis of marked under-representation in studies to date – developing and sharing analytic workflows and new statistical genetics approaches. Second, using a ‘diversity-first’ approach, they plan to validate the FFAIR-PRS approach for enhanced polygenic score development, and build integrated and calibrated absolute risk estimators to facilitate ultimate clinical adoption via other ongoing research efforts.
NIH RePORTER link