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Education

The NIH-funded Polygenic Risk Methods in Diverse Populations (PRIMED) Consortium is developing and evaluating methods to improve the use of polygenic risk scores (PRS) to predict disease and health outcomes in diverse ancestry populations.

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What are Polygenic Risk Scores?

Below are links to explanatory articles on PRS, including the science behind them, challenges and opportunities, and ongoing research.

 

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Videos

Learn more about the work and the people involved in the following videos of PRIMED investigators (indicated with PRIMED Site affiliation below) and other experts in the field.

Tutorials

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Hands-on tutorial of using PRS-CSx to perform multi-ancestry PRS analysis
(8:28, on YouTube)
Yunfeng Ruan (FFAIRR-PRS)
Jun 29, 2023: Psychiatric Genomics Consortium (PGC)

 

Harmonizing Data

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Cohort Data Harmonization Example 3: PRIMED
(23:06, on YouTube)
Leslie Lange (CAPE)
Jul 13, 2022: CINECA Project, Data Harmonization Workshop

 

Clinical Implementation

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Working Towards Equity in Genomic Medicine: A Clinician-Investigator's Perspective
(57:43, on YouTube)
Iftikhar Kullo (PREVENT)
Nov 7, 2022: National Human Genome Research Institute, Genomics and Health Disparities Lecture Series

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PRS for the PCP: Evaluating polygenic risk scoring in primary care with clinical trials
(1:10:16, on YouTube)
Katrina A.B. Goddard (NCI) and Jason L. Vassy (HMS, VA, and Brigham and Women’s Hospital)
Oct 18, 2023: National Human Genome Research Institute, Genomic Innovator Seminar Series

 

Health Disparities

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Prioritizing Genetics to Reduce Existing Health Disparities
(1:02:12, on NIH VideCast)
Nancy J. Cox (D-PRISM, EPIC-PRS)
Feb 1, 2024: WALS NIH Director’s Wednesday Afternoon Lecture Series

 

Ethical and Social Considerations

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Polygenic Risk Prediction in Diverse Populations and Contexts: Scientific and Ethical Considerations
(55:36, on ELSIhub)
Malia Fullerton, DPhil (PRIMED Coordinating Center) and Alicia Martin, PhD (FFAIRR-PRS)
Jan 12, 2024: ELSI Friday Forum

This webinar explores the scientific and ethical considerations relevant to the widespread adoption of PRS for clinical care.

 

Other

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Concept Clearance: Polygenic Risk Scores from Populations of Diverse Ancestry RFAs
(1:07:22, on YouTube)
Lucia Hindorff (NHGRI)
Sep 16, 2019 - National Advisory Council for Human Genome Research (Open Session)

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