Diabetes Polygenic RIsk Scores in Multiple ancestries (D-PRISM)

Diabetes Polygenic RIsk Scores in Multiple ancestries (D-PRISM) is led by Josep Mercader (contact PI) and Alisa Manning (MPI) from the Broad and Maggie Ng (MPI) from VUMC, along with 32 co-investigators across 5 countries. D-PRISM work will focus on improving polygenic risk score prediction of diabetes and progression across the lifespan in diverse ancestries using the PRS-CS method and its extensions. Their study includes more than 1.5M individuals with type 1 and type 2 diabetes, gestational diabetes and/or related complications from diverse ancestries. Results from this study will demonstrate how genomic data can inform more efficient and targeted preventive strategies within healthcare systems and across ethnically diverse populations.