Yun Li (UNC, contact PI), Nancy Cox (VUMC, MPI), and Alex Reiner (FHCRC/UW, MPI) are leading a study site that will focus on creating PRS-adjusted laboratory values, which are used routinely for diagnosing and monitoring the progression of disease but manifest substantial differences across racial/ethnic groups. They anticipate these PRS-adjusted laboratory values will reduce structural health disparities and improve prediction of relevant clinical endpoints. They additionally leverage important aspects of population genetics, including local ancestry information and population-specific selection signatures, to construct better predictive PRS in admixed populations.
NIH RePORTER link
PI