The NIH-funded Polygenic Risk Methods in Diverse Populations (PRIMED) Consortium is developing and evaluating methods to improve the use of polygenic risk scores (PRS) to predict disease and health outcomes in diverse ancestry populations. 

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PRIMED Consortium goals, working groups, products, and structure
Publication of PRIMED Perspective in AJHG

The PRIMED Perspective manuscript has been published, viewable on the AJHG website and ScienceDirect. In brief, this Consortium marker paper describes the PRIMED Consortium and organization of its activities, and highlights methodological innovations and early products, with the goal of facilitating additional initiatives that aim to reduce inequity in genomic medicine.

Kullo, I. J., Conomos, M. P., Nelson, S. C., Adebamowo, S. N., Choudhury, A., Conti, D., Fullerton, S. M., Gogarten, S. M., Heavner, B., Hornsby, W. E., Kenny, E. E., Khan, A., Khera, A. v., Li, Y., Martin, I., Mercader, J. M., Ng, M., Raffield, L. M., Reiner, A., … Zhong, M. (2024). The PRIMED Consortium: Reducing disparities in polygenic risk assessment. The American Journal of Human Genetics. https://doi.org/10.1016/j.ajhg.2024.10.010


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Recent publications
Thomas Gilliland, et al. Genetic Architecture and Clinical Outcomes of Combined Lipid Disturbances Circulation Research.
Iftikhar Kullo, Matt Conomos, Sarah Nelson, et al. The PRIMED Consortium: Reducing disparities in polygenic risk assessment American Journal of Human Genetics.

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