The NIH-funded Polygenic Risk Methods in Diverse Populations (PRIMED) Consortium is developing and evaluating methods to improve the use of polygenic risk scores (PRS) to predict disease and health outcomes in diverse ancestry populations. 

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A funnel decorated with computer circuits compiles information from many DNA sequences into one polygenic risk score.
Researchers roll out a more accurate way to estimate genetic risks of disease

PRIMED researchers from the FFAIRR-PRS Site have developed new methods to integrate multiple polygenic risk scores to produce more accurate predictions across diverse ancestries. The methods, called PRSMix and PRSMix+, are published in Cell Genomics, featured in a Broad Institute press release, and publicly available on the NHGRI AnVIL cloud platform.

Image by Ricardo Job-Reese, Broad Institute of MIT and Harvard.


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Colorful image of multiple open journals. Image by kconcha from Pixabay.
Recent publications
Interplay Of Serum Bilirubin and Tobacco Smoking with Lung and Head and Neck Cancers in a Diverse, EHR-linked Los Angeles Biobank .
Hou, et al. Calibrated prediction intervals for polygenic scores across diverse contexts .

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